Don't Transfect, Just Deliver!

Name: Gateway
Brand: Portal

Multi cargo. High viability. Better delivery.

Get Boosting with The Gateway™ System

What’s included

Gateway™ System

6 Months White Glove Technical Support

Booster™ Subscription

Cell Engineering Kits

Validated biological workflows — a one stop shop.

Every kit includes: Portal-sourced RNA · Optimized protocols · MicroBooster™ cartridges · Suggested readouts · Reagents

CELL THERAPY

T Cell Functional Enhancement

Best suited for: Human T cells (activated or unstimulated), PBMCs
Available enhancements: mbIL2, mbIL12, Perforin, Gzmb, B2M and TCR knockouts
Measure endogenous intracellular proteins in live cells
Use cases: Cytokine armoring, gene KO, persistence enhancement

Download Info

STEM CELL BIOLOGY

iPSC Generation

Best suited for: PBMCs & fibroblasts
Available enhancements: Oct4, Sox2, Klf4, cMyc RNA
Best suited for: Reprogramming, disease modeling

Download Info

IMMUNOLOGY

APC Enhancement

Best suited for: PBMCs, dendritic cells
Available enhancements: mbIL2, mbIL12, CD86, custom antigen RNA
Best suited for: Immune activation, DC engineering, vaccine research

Download Info

Stem cell biology

HSC Enhancement

Best suited for: Hematopoietic stem cells
Available enhancements: CXCR4, BCL2
Best suited for: Engraftment, survival, stemness preservation

Download Info

NEUROSCIENCE

Neuronal Differentiation

Best suited for: iPSC-derived neurons, neural progenitors
Available enhancements: NGN2, ASCL1, LMX1A, FOXA2, NURR1, ASOs
Best suited for: Neuronal differentiation, disease modeling, Parkinson's/ALS

Download Info

CELL ENGINEERING

Engineered Cell Purifciation

Enriches engineered cell populations for assays, differentiation, or transplantation
Enhancements: antibiotic-resistance mRNA markers, self-amplifying RNA, protein, or RNP cargo
Measures purity, viability, and cargo expression post-selection
Use cases: purifying reporter-positive cells, enriching through 3D differentiation, cleaning up mixed-delivery pools

Download Info

Drug Discovery Kits

Validated live-cell workflows for target engagement, compound profiling, and beyond.

Every kit includes: Cargoes · Optimized protocols · MicroBooster™ cartridges · Suggested readouts · Reagents

Impermeable Candidate Validation in Live Cells

Solves: Permeability engineering as a prerequisite for testing cellular activity
Cargo: Your impermeable drug candidate
Validate and test your candidates in live cells, regardless of permeability
e.g. small molecules, macrocycles, peptides

Download Info

Live-Cell Protein Detection

Solves: Live-cell context lost to lysis, and target labeling that requires cell engineering.
Cargo: Intracellular antibodies (primary & secondary)
Measure endogenous intracellular proteins in live cells
e.g. p-BTK, p-ERK, p-AKT, p-STAT3, p-MET Compatible with LgBiT/HgBiT reagents

Download Info

Live-Cell Target Engagement

Solves: Live-cell context lost to lysis and detergents, and the need to create cell-permeable tracers
Cargoes: Your tracers (e.g. NanoBRET) and compounds
Enables live-cell target engagement without lysis; supports impermeable tracers
e.g. kinase inhibitor profiling, degrader engagement

Download Info

Controllable Surface Receptor Expression

Solves: Fixed, hard-to-modulate surface antigen expression in cell lines
Cargo: Custom antigen/receptor RNA — single or combinations
Express any antigen on any cell in hours
e.g. CD19+CD3, BCMA+CD3, HER2+CD3

Download Info

Direct-to-Assay

Solves: The stable-line bottleneck: infeasible in primary cells, slow and laborious elsewhere
Cargo: Custom RNA encoding tagged POI
Run NanoBRET or LgBiT/HgBiT without stable lines
e.g. VHL-NanoLuc, HgBiT-tagged POI, HA-tagged POI

Download Info